Table 1. The in vitro activity of 11 antimicrobial agents against K. kingae
|
Antibiotic |
MIC50 (ug/ml) |
MIC90 (ug/ml) |
MIC RANGE (ug/ml) |
|
AMPICILLIN |
0.004 |
0.008 |
0.004 - 0.06 |
|
PENICILLIN G |
0.008 |
0.015 |
0.004 |
|
CEPHALOTHIN |
0.25 |
0.25 |
0.125 - 0.25 |
|
CEFUROXIME |
0.008 |
0.03 |
0.008 - 0.06 |
|
CEFTRIAXONE 1 2 |
<0.008 0.015 |
0.06 0.015 |
<0.008 - 0.06 0.008 - 0.015 |
|
CHLORAMPHENICOL |
0.5 |
1.0 |
0.25 - 2.0 |
|
CIPROFLOXACIN 1 2 |
0.06 0.004 |
1.0 0.004 |
0.03 - 4.0 <0.002 - 0.008 |
|
GENTAMICIN 1 2 |
2.0 0.06 |
4.0 0.5 |
0.5 - 8.0 0.03 - 0.5 |
|
ERYTHROMYCIN |
0.125 |
0.5 |
0.06 - 1.0 |
|
IMIPENEM |
0.03 |
0.03 |
<0.008 - 0.03 |
|
MEROPENEM |
<0.008 |
0.015 |
<0.008 - 0.12 |
1. (4)
2. (8)
Table 2. The in vitro activity of
29 antimicrobial agents against K. kingae
|
Antibiotic |
MIC50 (ug/ml) |
MIC Range (ug/ml) |
|
Ampicillin |
<0.016 |
<0.016 - 6 |
|
Oxacillin |
2 |
0.25 - 96 |
|
Penicillin |
0.012 |
0.003 - 8 |
|
Ticarcillin |
<0.016 |
<0.016 - 16 |
|
Ampicillin / Sulbactam |
<0.016 |
<0.016 - 4 |
|
Piperacillin / Tazobactam |
<0.016 |
<0.016 |
|
Cefprozil |
0.19 |
<0.016 - >256 |
|
Cefixime |
<0.016 |
<0.016 - 3 |
|
Ceftibuten |
0.094 |
<0.016 - 4 |
|
Cefpodoxime |
<0.016 |
<0.016 - 4 |
|
Cefdinir |
0.032 |
<0.016 - 8 |
|
Cefuroxime |
0.023 |
<0.016 - 256 |
|
Cefoxitin |
<0.016 |
<0.016 - 48 |
|
Cefotaxime |
0.016 |
<0.002 - 1 |
|
Ceftriaxone |
0.008 |
<0.002 - 4 |
|
Ceftazidime |
0.094 |
<0.016 - 4 |
|
Cefepime |
0.125 |
0.032 - 3 |
|
Cefpirome |
0.064 |
<0.016 - >256 |
|
Imipenem |
0.047 |
0.023 - 0.094 |
|
Meropenem |
0.008 |
0.004 - 0.25 |
|
Ciprofloxacin |
0.023 |
0.006 - 0.032 |
|
Clinafloxacin |
0.006 |
0.004 - 0.012 |
|
Grepafloxacin |
0.023 |
0.012 - 0.032 |
|
Levofloxacin |
0.047 |
0.023 - 0.064 |
|
Ofloxacin |
0.094 |
0.047 - 0.125 |
|
Sparfloxacin |
0.032 |
0.012 - 0.047 |
|
Trovafloxacin |
0.023 |
0.012 - 0.047 |
|
Rifampin |
0.125 |
0.064 - 0.5 |
|
Trimethoprim / Sulfamethoxazole |
0.064 |
0.032 - 0.5 |
Table 3.
Antimicrobial dosages for adults and
children in osteoarticular infections
|
Antibiotic |
Adult |
Children |
|
Ampicillin |
1.0 g iv q 6 hr |
25 mg/kg iv q 6 hr |
|
Penicillin G |
12 - 18 M units/d iv divided q 4 - 6 hr |
200,000 units/kg/d iv divided q 6 hr |
|
Cefuroxime |
1.5 g iv q 8 hr |
150 mg/kg/d iv divided q 8 hr |
|
Cefotaxime |
2.0 g iv q 6 hr |
150 mg/kg/d iv divided q 8 hr |
|
Amoxicillin |
500 mg po q 8 hr |
100mg/kg/d po divided q 6 hr |
|
Penicillin VK |
500 mg po q 6 hr |
150 mg/kg/d po divided q 6 hr |
|
Dicloxacillin |
500 mg po q 6 hr |
100 mg/kg/d po divided q 6 hr |