Current Designation

Previous or Alternative Names (s)

Corynebacterium accolens

CDC group G-1

Corynebacterium amycolatum

CDC group F-2 and I-2

Corynebacterium jeikeium

CDC group JK

Corynebacterium pseudotuberculosis

Corynebacterium ovis

Corynebacterium pseudodiphtheriticum

Corynebacterium hofmannii

Arcanobaterium haemolyticum

Corynebacterium haemolyticum

C. afermentans subsp. lipophilum

CDC group ANF-1

Bifidobacterium adolescontis

CDC group E

Corynebacterium urealyticum

CDC group D-2

Corynebacterium glucuronolyticum

Corynebacterium seminale

Almost certainly significant, treatment mandatory:

• Isolation of the same species from more than two blood cultures; regardless of the presence of other possible pathogens
• Isolation from a specimen from a normally sterile site obtained during surgery or by another aseptic procedure (e.g. aspiration of ascites, pleura, joint or SCF) in a patients with a compatible clinical syndrome

Probably significant, treatment mandatory because of severity of illness:

• Isolation in one culture of blood or other normally sterile body fluid from a patient with sepsis or signs of impending sepsis
• Isolation in one blood culture from a febrile immunocompromised patients if not other cause for fever is identified
• Isolation as the sole organism in one blood culture from a patients with clinical or echocardiographic evidence of endocarditis

Possibly significant, treatment or further diagnostic evaluation indicated:

• Isolation as the sole organism in one blood culture from a febrile patient with a prosthetic heart valve but no other signs of endocarditis
• Isolation in conjunction with other possible pathogens from a normally sterile body fluid or site

Probably not significant, do not treat unless further evidence supports a pathogenic role:

• Isolation from improperly obtained blood culture or from a normally sterile specimen yielding other probably contaminants

Antibiotic

MIC50 (mg/ml)

MIC90 (mg/ml)

Range (mg/ml)

Breakpoint (mg/ml)*

Reference

C. amycolatum

Penicillin

1

4

0.12-4

< 1

(14)

Tetracycline

-

-

-

< 0.5

(14)

Erythromycin

> 8

> 8

≤ 0.25 - >8

< 0.5

(14)

Clindamycin

> 8

> 8

≤ 0.25 - >8

< 1

(14)

Ciprofloxacin

> 4

> 4

≤ 0.25 - >4

< 4

(14)

Vancomycin

< 0.5

< 0.5

≤ 0.5 - 2

< 4

(14)

Gentamicin

4

8

≤ 1 - > 8

< 4

(14)

Linezolid

0.25

0.25

≤ 0.12 – 0.5

< 2

(14)

Daptomycin

0.06

0.06

0.125

< 1

(11)

Quinupristin-dalfopristin

0.25

0.25

0.125-0.25

< 1

(11)

C. jeikeium

Penicillin

> 4

> 4

0.12 - > 4-

≤ 1

(14)

Tetracycline

-

-

-

-

(14)

Erythromycin

> 8

> 8

≤0.25 - >8

≤ 0.5

(14)

Clindamycin

> 8

> 8

≤0.25 - >8

≤ 0.5

(14)

Ciprofloxacin

> 4

> 4

≤0.25 - >4

≤ 1

(14)

Vancomycin

< 0.5

1

≤0.5 – 1

≤ 4

(14)

Linezolid

0.5

0.5

0.25 – 1

≤ 2

(14)

Gentamicin

2

> 8

≤ 1 - > 8

≤ 4

(14)

Daptomycin*

0.25

0.25

0.125 – 0.5

≤ 1

(12)

Quinupristin-dalfopristin

0.25

0.25

0.25 - 1

≤ 1

(12)

C. striatum

Penicillin

1

2

0.12 - > 4

< 1

(14)

Tetracycline

-

-

-

-

Erythromycin

2

1

< 0.25 - > 8

< 0.5

(14)

Clindamycin

> 8

> 8

< 0.25 - > 8

< 0.5

(14)

Ciprofloxacin

< 0.25

> 4

< 0.25 - > 8

< 1

(14)

Vancomycin

< 0.5

< 0.5

< 0.5 - 1

< 4

(14)

Gentamicin

< 1

2

< 1 - > 4

< 4

(14)

Linezolid

0.5

0.5

0.25 – 1

< 2

(14)

Daptomycin

-

-

-

-

Quinupristin-dalfopristin

-

-

-

-

C. urealyticum

Penicillin

0.5

>4

≤ 0.12 – 4

≤ 1

(14)

Tetracycline

-

-

-

-

Erythromycin

>8

>8

>8

≤ 0.5

(14)

Clindamycin

>8

>8

≤0.25 - >8

≤ 0.5

(14)

Ciprofloxacin

≤0.25

>4

≤0.25 - >4

≤ 1

(14)

Vancomycin

≤0.5

≤0.5

≤0.5

≤ 4

(14)

Gentamicin

≤ 1

>8

≤ 1 - > 8

≤ 4

(14)

Linezolid

0.5

0.5

0.25 - 1

≤ 2

(14)

Daptomycin

-

-

-

-

Quinupristin-dalfopristin

-

-

-

-