Table 1: In vitro Susceptibility of S. maltophilia to Selected Antibiotics

Antibiotic	MIC₅₀ mg/ml (range)	MIC₉₀ mg/ml (range)	% of strains susceptible*	% of strains resistant*	No. of strains tested†	References
TMP-SMZ	0·25 to >64‡	0·25 to >64	0 to 100§	4 to 100	3872	^{82, 23, 47, 94, 78, 75, 7, 98, 74, 88, 102, 85, 62}
Ticarcillin	16 to 512	64 to >1024	29 to 69	32 to 74	329	^{47, 7, 85}
TIM	2 to 128	32 to >1024	27 to 95	14 to 50	3764	^{82, 23, 47, 94, 78, 75, 7, 81, 74, 88, 85, 62}
Cefepime	16 to 64	>16 to ≥128	0 to 30	45 to 100	2508	^{23, 94, 7, 74, 102, 85}
Cefotaxime	60 to ≥64	≥64 to 512	10	62 to 64	249	^{7, 85}
Ceftazidime	8 to 128	>16 to 256	5 to 53	34 to 86	2649	^{82, 23, 47, 94, 7, 74, 88, 85}
Ceftriaxone	>32 to 256	>32 to >256	1 to 2	92 to 96	2184	^{74, 102}
Aztreonam	>16 to 256	>16 to >1024	0 to 10	85 to 100	2347	^{94, 7, 74, 85}
Norfloxacin	16 to ≥16	≥16 to 64	20	56	358	^{7, 85, 84}
Ofloxacin	0·5 to 0·5	4 to 4	89	5	208	^{85, 84}
Ciprofloxacin	0·25 to >8	2 to 32	0 to 82	13 to 96	3865	^{82, 23, 47, 94, 78, 7, 98, 74, 88, 102, 85, 84}
Gatifloxacin	0·1 to 4	0·12 to 16	23 to 97	0 to 46	2642	^{23, 94, 98, 74, 85, 62}
Levofloxacin	0·2 to 2	2 to 8	55 to 86	3 to 11	2631	^{94, 98, 74, 102, 85}
Moxifloxacin	0·06 to 0·5	0·5 to 4	85	6	1405	^{30, 98, 102, 85, 84}
Doxycycline	1 to 2	2 to 8	80 to 100	1 to 11	968	^{47, 78, 75, 85, 62}
Minocycline	0·2 to 1	1 to 4	91 to 100	0 to 5	1014	^{94, 30, 88, 85}
Tetracycline	>8 to 32	>8 to 64	8 to 9	70 to 86	2325	^{7, 74, 85}
Tigecycline	1 to 1	2 to 4	90	3	239	^{102, 73}
Polymixin B	1 to 2	4 to 8	72 to 77	28	1322	^{62, 31}
Chloramphenicol	4 to 32	16 to 64	1 to 80	35 to 39	395	^{47, 7, 85, 62}
Amikacin	>32 to 512	>32 to >512	0 to 31	61 to 100	2535	^{47, 94, 7, 74, 102, 85}
Gentamicin	>8 to 64	>8 to >256	14 to 31	58 to 81	2433	^{7, 74, 102, 85}
Tobramycin	≥16 to 64	≥16 to 512	2 to 25	68 to 78	2405	^{47, 7, 74, 85}
Imipenem	>8 to 512	>8 to >1024	0 to 2	97 to 100	3261	^{23, 47, 78, 7, 74, 88, 85}
Meropenem	>8 to >64	>8 to 256	0 to 4	88 to 100	2433	^{7, 74, 102, 85}

Table 2. Antimicrobial Agents Used in Treatment of S. maltophilia Infections. [Download PDF]

Drug	Dose
Trimethoprim/sulfamethoxazole	15mg/kg/day divided in 2 to 3 doses
Ticarcillin/clavulanate	3.1 g q6h IV
Ceftazidime	2 gm q8h IV
Ciprofloxacin	400 mg q12h IV
Levofloxacin	500-750 mg q24h IV
Moxifloxacin	1 x 400mg/day
Doxycycline	100 mg q12h IV