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Clostridium difficile
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Sliding Table of
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Tables and Figures
Table 1: Randomized, Comparative Trials of Oral Therapy for Clostridium
difficile Diarrhea
Table 2: Empirical Treatment Strategies for Patients with Multiple
Recurrences of C. difficile Diarrhea
Table 3: Potential Future Treatment Options
Figure 1: Three Hit Disease
Vignettes
Bartlett
JG.
Historical Perspectives on Studies of Clostridium
difficile and C. difficile infection.
Clin Infect Dis 2008;46(Suppl 1):S4-S11.
Johnson, S, Schriever C, Galang M, Kelly CP,
Gerding DN.
Interruption of recurrent Clostridium
difficile-Associated Diarrhea Episodes by Serial Therapy with Vancomycin
and Rifaximin. Clin Infect Dis 2007;44:846-848.
Bobulsky GS,
Al-Nassir WN,
et al.
Clostridium difficile skin contamination in
patients with C. difficile-associated disease. Clin Infect Dis
2008;46(3):447-50.
Redelings MD, Sorvillo F,
Mascola L.
Increase in Clostridium difficile-related
Mortality Rates, United States, 1999-2004. Emerg Infect Dis
2007;13:1417-1419.
Juang P, et al.
Clinical outcomes of intravenous immune globulin in severe clostridium
difficile-associated diarrhea.
Am J Infect Control
2007;35:131-137.
Pepin J, Valiquette L, Gagnon S,
Routhier S, Brazeau I.
Outcomes of Clostridium difficile-Associated Disease
Treated with Metronidazole or Vancomycin Before and After the Emergency of
NAP1/027. Am J Gastroenterol 2007 Sep
27; [Epub ahead of print].
Bakken J.
Fecal Bacteriotherapy for Relapsing Clostridium
difficile Infection. 2009
Zar FA, Bakkanagari SR, et al.
A Comparison of Vancomycin and Metronidazole for the
Treatment of Clostridium difficile-Associated Diarrhea, Stratified by
Disease Severity. Clin Infect Dis. 2007;45:302-7.
Lee NY, et al.
Clostridium difficile
Bacteremia, Taiwan. Emerg Infect Dis 2010;16:1204-1210.
Tung JM, et al.
Prevention of
Clostridium difficile Infection with Saccharomyces boulardii: A Systematic
Review. Can J Gastroenterol. 2009 Dec;23:817-21.
Guideline: Cohen SH, et al.
Clinical Practice Guidelines for Clostridium difficile infection in
adults: 2010 update by the society for healthcare epidemiology of America
(SHEA) and hte infectious diseases society of America (IDSA). Infect
Control Hosp Epidemiol (U.S.). 2010;31(5):431-455.
Review Article: McMaster-Baxter NL, Musher DM.
Clostridium difficile: Recent Epidemiological Findings and
Advances In Therapy. Pharmacotherapy 2007;27(7):1029-1039.
Authors:
Hoonmo L. Koo, M.D., M.P.H. and Daniel M.
Musher, M.D.
Author of Previous Edition:
Robert C. Owens, Jr., Pharm.D.,
 Stuart Johnson, M.D.,
 Dale N. Gerding, M.D.
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