Table 1. Bactericidal Concentrations of Antibiotics Against K. granulomatis Reported by Chen (1951)(4).
|
Antibiotic |
Bactericidal concentration per ml of medium |
|
Streptomycin |
0.2 mg |
|
Penicillin G |
1 unit |
|
Chlortetracycline |
5 mg |
|
Chloramphenicol |
10 mg |
From Chen CH, Dienst RB, Greenblatt RB. Antibiotics versus Donovania granulomatis. Am J Syphilis 1951:35:383-392.
Table 2. Key Trials of Antibiotics for Treatment of Granuloma Inguinale
|
Drug |
Dose |
Route |
Duration |
M:F |
Total patients |
Smear positive |
Relapse |
Days to smear negative |
Days to heal |
Ref |
|
Ampicillin |
500 mg qid |
O |
2-4wk |
|
31 |
67% |
|
|
|
|
|
Chloramphenicol |
500mg-1g 6h |
O |
5-20d |
0/23 |
23 |
|
2 |
2-4 days |
|
|
|
" |
2-4g every 3-4 days |
IM |
8-12d |
20/23 |
43 |
43 |
5 |
1-7 days |
7-30d |
|
|
" |
500mg qid |
O |
10-55d |
|
50 |
|
1 |
av. 7 days |
av.17d |
|
|
Thiamphenicol |
2.5g stat, then 500mg bd |
O |
1-3wk |
26/8 |
34 |
34 |
|
1-3 weeks |
1-3wk |
|
|
Co-trimoxazole |
160/800mg, bd |
O |
Mean 12.5d |
84/32 |
116 |
116 |
2 |
5 days |
7-22d |
|
|
" |
160/800mg, bd |
O |
20-49d |
19/1 |
20 |
16 |
|
|
2-5wk |
|
|
" |
160/800mg, bd |
O |
14d |
12/6 |
18 |
18 |
|
|
7-21d |
|
|
Erythromycin |
1-300mg 6h |
O |
16-37d |
5/4 |
9 |
9 |
1 |
|
9-30d |
|
|
Lincomycin |
500mg qid |
O |
14d |
|
5 |
|
|
|
|
|
|
Streptomycin |
0.3-1g 4h |
IM |
6-46d |
|
23 |
23 |
3 |
5-9 days |
|
|
|
" |
0.3-4g/d |
IM |
5-62d |
32/16 |
48 |
48 |
3 |
2-11 days |
av. 3wk |
|
|
" |
1g bd |
IM |
3-70d |
146/81 |
227 |
219 |
1 |
av. 6 days |
|
|
|
" |
1g bd |
IM |
av.12.5d |
83/39 |
122 |
|
|
|
|
|
|
Gentamicin |
1mg/kg tds |
IM |
mean 22d |
|
9 |
|
|
mean 12 days |
mean 22d |
|
Tetracyclines |
|
|
|
|
|
|
|
|
|
|
|
Minocycline |
200mg stat, then 100mg bd |
O |
15-45d |
5/1 |
6 |
6 |
|
|
15-90d |
|
|
" |
100-300mg/d |
O |
max 58d |
1/9 |
10 |
10 |
|
|
|
|
|
Oxytetracycline |
2-3g/d |
O |
2-29d |
|
32 |
32 |
2 |
4-5 days |
|
|
|
Tetracycline hydrochloride |
1g/d |
O |
20d |
14/6 |
20 |
20 |
|
5-7 days |
25-45d |
|
|
Norfloxacin |
400mg bd |
O |
2-11d |
10/0 |
10 |
10 |
|
8 by 3 days |
mean 7.3d |
|
|
Ceftriaxone |
1g od |
IM/IV |
10d |
4/8 |
12 |
8 |
5 |
|
|
|
|
Azithromycin |
1g per week or 500mg daily |
O |
1-4 wk |
4/7 |
11 |
9 |
0 |
|
|
|
|
Antibiotic combinations |
|
|
|
|
|
|
|
|
|
|
|
Streptomycin with |
1g/d |
IM |
14d |
7/6 |
13 |
13 |
|
|
7-21d |
|
|
tetracycline |
500mg 6h |
O |
14d |
|
|
|
|
|
|
|
|
Erythromycin with |
500mg qid |
O |
10-14d |
0/4 |
4 |
4 |
|
|
"rapid" |
|
|
Lincomycin |
500mg qid |
O |
10-14d |
|
|
|
|
|
|
|